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Michael G. DeGroote Institute for Infectious Disease Research, McMaster University

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antibiotic resistance bioinformatics databases genomics ontologies publications

CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database

October 20, 2022 agmcarthur

Alcock et al. 2023. Nucleic Acids Res Oct 20, 2022:gkac920. (online ahead of print) The Comprehensive Antibiotic Resistance Database (CARD; card.mcmaster.ca) combines the Antibiotic Resistance

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antibiotic resistance bioinformatics genomics software

Resistome Gene Identifier (RGI) version 6.0.0

September 12, 2022May 25, 2023 agmcarthur

RGI version 6.0.0 – Major release, with parameter and reference data loading changes that may impact scripts. Please see updated README. Added an option (–keep)

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antibiotic resistance bioinformatics genomics lab members

Welcome new M.Sc. student Mateusz Wlodarski!

September 8, 2022October 4, 2022 agmcarthur

The McArthur lab welcomes back past undergraduate student and now newly minted Biochemistry & Biomedical Sciences M.Sc. student Mateusz Wlodarski! Mateusz will be working on

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antibiotic resistance genomics publications

Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation

August 26, 2022September 8, 2022 agmcarthur

Guitor et al. 2022. Microbiome 10(1):136. Background: Probiotic use in preterm infants can mitigate the impact of antibiotic exposure and reduce rates of certain illnesses;

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antibiotic resistance genomics molecular epidemiology presentations SARS-CoV-2 text mining virus epidemiology volunteers

Summer Conferences 2022

July 2, 2022July 2, 2022 agmcarthur

(presenters in bold; lab members underlined) Baker, S.J.C., S. Yaqoob, M.-T. Usuanlele, J. Gilchrist, M. Smieja, M. Loeb, S. Khan, J. Pernica, M.G. Surette, A.G.

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antibiotic resistance big data bioinformatics genomics publications

Datasets for benchmarking antimicrobial resistance genes in bacterial metagenomic and whole genome sequencing

June 15, 2022June 15, 2022 agmcarthur

Raphenya et al. Scientific Data volume 9, Article number: 341 (2022). Whole genome sequencing (WGS) is a key tool in identifying and characterising disease-associated bacteria

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antibiotic resistance genomes genomics

MACGENOM Survey Results

June 14, 2022June 14, 2022 Mugdha Dave

The burden of drug-resistant infections continues to threaten our arsenal of antibiotics. Despite the rise in genomic sequencing of clinical isolates, there is a lack

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antibiotic resistance bioinformatics genomics publications

Performance characteristics of next-generation sequencing for the detection of antimicrobial resistance determinants in Escherichia coli genomes and metagenomes

June 1, 2022June 2, 2022 agmcarthur

Rooney et al. 2022 Jun 1;e0002222. Short-read sequencing can provide detection of multiple genomic determinants of antimicrobial resistance from single bacterial genomes and metagenomic samples.

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antibiotic resistance big data genomics publications

Machine learning for antimicrobial resistance prediction: current practice, limitations, and clinical perspective

May 26, 2022May 26, 2022 agmcarthur

Kim et al. Clin Microbiol Rev. 2022 May 25;e0017921. Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern medicine.

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antibiotic resistance bioinformatics databases genomics molecular epidemiology publications software

Enabling genomic island prediction and comparison in multiple genomes to investigate bacterial evolution and outbreaks

May 19, 2022 agmcarthur

Bertelli et al. Microb Genom. 2022 May;8(5). doi: 10.1099/mgen.0.000818. Outbreaks of virulent and/or drug-resistant bacteria have a significant impact on human health and major economic

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antibiotic resistance big data bioinformatics genomics publications software

Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents

April 13, 2022 agmcarthur

Sanderson et al. 2022. bioRxiv 10.1101/2022.04.11.487771. Enterococcus faecium is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the

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antibiotic resistance bioinformatics genomics IIDR lab members presentations software

Biochemistry & Biomedical Sciences Research Symposium (BBSRS) 2022!

March 2, 2022March 2, 2022 agmcarthur

Karyn Mukiri – Predicting the Total Resistome Mugdha Dave – Creation and standardization of automated bacterial pathogen genomic sequencing reporting through informatics

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antibiotic resistance bioinformatics genomics IIDR lab members molecular epidemiology

Welcome Madeline McCarthy!

January 4, 2022 agmcarthur

The McArthur lab welcomes Madeline McCarthy, a recent MSc graduate of VIDO / USask, as she join us for her PhD studies in the McMaster

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awards COVID19 epidemiology genomics IIDR lab members molecular epidemiology SARS-CoV-2 virus epidemiology

Emily Panousis wins the Michael Kamin Hart Memorial Undergraduate Scholarship for her work on SARS-CoV-2 surveillance!

November 3, 2021November 5, 2021 agmcarthur

More information about IIDR Trainee Day and Michael Kamin Hart here.

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antibiotic resistance databases genomics lab members news

Farewell William!

August 31, 2021August 24, 2021 agmcarthur

Today we say goodbye to William Huynh, who first joined us as an undergraduate thesis student and then stayed on to work as the Comprehensive

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awards bioinformatics epidemiology genomics IIDR lab members news SARS-CoV-2 software virus epidemiology

Jalees Nasir awarded 2021 Fred & Helen Knight Enrichment Award!

July 14, 2021July 14, 2021 agmcarthur

Congratulations to PhD student Jalees Nasir, who has been awarded the prestigious 2021 Fred & Helen Knight Enrichment Award, which recognizes exceptional promise in early

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antibiotic resistance genomics lab members

Congratulations Kara Tsang on the completion of your Ph.D.!

July 9, 2021July 9, 2021 agmcarthur
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antibiotic resistance bioinformatics genomics lab members presentations

Summer Conferences 2021

July 5, 2021July 5, 2021 agmcarthur

All online this year due to COVID-19, but some great presentations and virtual posters by our trainees and collaborators! Edalatmand, A. & A.G. McArthur. 2021.

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antibiotic resistance bioinformatics genomics publications

Performance characteristics of next-generation sequencing for antimicrobial resistance gene detection in genomes and metagenomes

June 29, 2021June 29, 2021 agmcarthur

Ashley M. Rooney, Amogelang R. Raphenya, Roberto G. Melano, Christine Seah, Noelle R. Yee, Derek R. MacFadden, Andrew G. McArthur, Pierre H.H. Schneeberger, Bryan Coburn.

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COVID19 genomics molecular epidemiology publications SARS-CoV-2 virus epidemiology

Temporal dynamics and evolution of SARS-CoV-2 demonstrate the necessity of ongoing viral genome sequencing in Ontario, Canada

May 8, 2021May 8, 2021 agmcarthur

Sjaarda, C.P., J.L. Guthrie, S. Mubareka, J.T. Simpson, B. Hamelin, H. Wong, L. Mortimer, R. Slinger, A.G. McArthur, M. Desjardins, K. Douchant, Ontario’s COVID-19 Genomics

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