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Michael G. DeGroote Institute for Infectious Disease Research, McMaster University

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COVID19 genomics publications SARS-CoV-2 virus epidemiology

Sensitivity to neutralizing antibodies and resistance to Type I interferons in SARS-CoV-2 R.1 lineage variants, Canada

June 21, 2023June 21, 2023 agmcarthur

Jacob et al. Emerg Infect Dis. 2023 Jun 12;29(7). Isolating and characterizing emerging SARS-CoV-2 variants is key to understanding virus pathogenesis. In this study, we

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COVID19 genomics molecular epidemiology publications SARS-CoV-2 virus epidemiology

SARS-COV-2 outbreak investigation using contact tracing and whole-genome sequencing in an Ontario tertiary care hospital

May 6, 2023May 6, 2023 agmcarthur

Tsang et al. Microbiol Spectr. 2023 Apr 24;e0190022. Genomic epidemiology can facilitate an understanding of evolutionary history and transmission dynamics of a severe acute respiratory

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antibiotic resistance big data databases ontologies publications software

CARD*Shark: automated prioritization of literature curation for the Comprehensive Antibiotic Resistance Database

April 21, 2023April 21, 2023 agmcarthur

Arman Edalatmand & Andrew G McArthur. 2023. Database, doi: 10.1093/database/baad023. Scientific literature is published at a rate that makes manual data extraction a highly time-consuming

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antibiotic resistance bioinformatics databases genomics ontologies publications

CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database

October 20, 2022 agmcarthur

Alcock et al. 2023. Nucleic Acids Res Oct 20, 2022:gkac920. (online ahead of print) The Comprehensive Antibiotic Resistance Database (CARD; card.mcmaster.ca) combines the Antibiotic Resistance

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antibiotic resistance genomics publications

Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation

August 26, 2022September 8, 2022 agmcarthur

Guitor et al. 2022. Microbiome 10(1):136. Background: Probiotic use in preterm infants can mitigate the impact of antibiotic exposure and reduce rates of certain illnesses;

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big data clinical metadata epidemiology molecular epidemiology publications SARS-CoV-2 virus epidemiology

The Dataharmonizer: a Tool for Faster Data Harmonization, Validation, Aggregation, and Analysis of Pathogen Genomics Contextual Information

June 24, 2022June 24, 2022 agmcarthur

Gill et al. 2022. Preprints 10.20944/preprints202206.0335.v1 Pathogen genomics is a critical tool for public health surveillance, infection control, outbreak investigations, as well as research. In

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antibiotic resistance big data bioinformatics genomics publications

Datasets for benchmarking antimicrobial resistance genes in bacterial metagenomic and whole genome sequencing

June 15, 2022June 15, 2022 agmcarthur

Raphenya et al. Scientific Data volume 9, Article number: 341 (2022). Whole genome sequencing (WGS) is a key tool in identifying and characterising disease-associated bacteria

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antibiotic resistance bioinformatics genomics publications

Performance characteristics of next-generation sequencing for the detection of antimicrobial resistance determinants in Escherichia coli genomes and metagenomes

June 1, 2022June 2, 2022 agmcarthur

Rooney et al. 2022 Jun 1;e0002222. Short-read sequencing can provide detection of multiple genomic determinants of antimicrobial resistance from single bacterial genomes and metagenomic samples.

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antibiotic resistance big data genomics publications

Machine learning for antimicrobial resistance prediction: current practice, limitations, and clinical perspective

May 26, 2022May 26, 2022 agmcarthur

Kim et al. Clin Microbiol Rev. 2022 May 25;e0017921. Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern medicine.

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antibiotic resistance bioinformatics databases genomics molecular epidemiology publications software

Enabling genomic island prediction and comparison in multiple genomes to investigate bacterial evolution and outbreaks

May 19, 2022 agmcarthur

Bertelli et al. Microb Genom. 2022 May;8(5). doi: 10.1099/mgen.0.000818. Outbreaks of virulent and/or drug-resistant bacteria have a significant impact on human health and major economic

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