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Michael G. DeGroote Institute for Infectious Disease Research, McMaster University

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antibiotic resistance bioinformatics genomics publications

Performance characteristics of next-generation sequencing for the detection of antimicrobial resistance determinants in Escherichia coli genomes and metagenomes

June 1, 2022June 2, 2022 agmcarthur

Rooney et al. 2022 Jun 1;e0002222. Short-read sequencing can provide detection of multiple genomic determinants of antimicrobial resistance from single bacterial genomes and metagenomic samples.

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antibiotic resistance big data genomics publications

Machine learning for antimicrobial resistance prediction: current practice, limitations, and clinical perspective

May 26, 2022May 26, 2022 agmcarthur

Kim et al. Clin Microbiol Rev. 2022 May 25;e0017921. Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern medicine.

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antibiotic resistance bioinformatics databases genomics molecular epidemiology publications software

Enabling genomic island prediction and comparison in multiple genomes to investigate bacterial evolution and outbreaks

May 19, 2022 agmcarthur

Bertelli et al. Microb Genom. 2022 May;8(5). doi: 10.1099/mgen.0.000818. Outbreaks of virulent and/or drug-resistant bacteria have a significant impact on human health and major economic

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publications

Metformin-induced reductions in tumor growth involves modulation of the gut microbiome

April 26, 2022 agmcarthur

Broadfield et al. Molecular Metabolism 2022. Apr 20;101498. Type 2 diabetes and obesity increase the risk of developing colorectal cancer (CRC). The first-line type 2

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antibiotic resistance big data bioinformatics genomics publications software

Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents

April 13, 2022 agmcarthur

Sanderson et al. 2022. bioRxiv 10.1101/2022.04.11.487771. Enterococcus faecium is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the

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COVID19 publications teaching

A survey on Canadian pediatric hospital clinical/medical teaching unit implementation during the first and second wave of the COVID-19 pandemic

November 11, 2021 agmcarthur

Kara K Tsang, Andrew Latchman, Nishma Singhal, Giuliana Federici, Sandra Russell, Denise Irwin, Robyn Stevens, Andrew G McArthur, & Sarah Khan BMC Med Educ. 2021

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publications

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

August 27, 2021August 27, 2021 agmcarthur

Wang, B., E.E. Tsakiridis, S. Zhang, A. Llanos, E.M. Desjardins, J.M. Yabut, A.E. Green, E.A. Day, B.K. Smith, J.S.V. Lally, J. Wu, A.R. Raphenya, K.A.

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COVID19 publications SARS-CoV-2 virus epidemiology

Evolutionary trajectory of SARS-CoV-2 and emerging variants

August 23, 2021August 27, 2021 agmcarthur

Jalen Singh, Pranav Pandit, Andrew G McArthur, Arinjay Banerjee, Karen Mossman Virology Journal. 2021 Aug 13;18(1):166. The emergence of a novel coronavirus, severe acute respiratory

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antibiotic resistance bioinformatics genomics publications

Performance characteristics of next-generation sequencing for antimicrobial resistance gene detection in genomes and metagenomes

June 29, 2021June 29, 2021 agmcarthur

Ashley M. Rooney, Amogelang R. Raphenya, Roberto G. Melano, Christine Seah, Noelle R. Yee, Derek R. MacFadden, Andrew G. McArthur, Pierre H.H. Schneeberger, Bryan Coburn.

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COVID19 publications SARS-CoV-2 virus epidemiology

Surface and air contamination with SARS-CoV-2 from hospitalized COVID-19 patients in Toronto, Canada

May 26, 2021May 26, 2021 agmcarthur

Kotwa et al. 2021. medRxiv https://doi.org/10.1101/2021.05.17.21257122 Background: The aim of this prospective cohort study was to determine the burden of SARS-CoV-2 in air and on

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bioinformatics ecotoxicogenomics P450 phylogenetics publications

The cytochrome P450 (CYP) superfamily in cnidarians

May 11, 2021 agmcarthur

Pankov, K.V., A.G. McArthur, D.A. Gold, D.R. Nelson, J.V. Goldstone, J.Y. Wilson. Scientific Reports. 2021 May 10;11(1):9834. The cytochrome P450 (CYP) superfamily is a diverse

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COVID19 genomics molecular epidemiology publications SARS-CoV-2 virus epidemiology

Temporal dynamics and evolution of SARS-CoV-2 demonstrate the necessity of ongoing viral genome sequencing in Ontario, Canada

May 8, 2021May 8, 2021 agmcarthur

Sjaarda, C.P., J.L. Guthrie, S. Mubareka, J.T. Simpson, B. Hamelin, H. Wong, L. Mortimer, R. Slinger, A.G. McArthur, M. Desjardins, K. Douchant, Ontario’s COVID-19 Genomics

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COVID19 publications SARS-CoV-2

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses

May 4, 2021 agmcarthur

Banerjee, A., N. El-Sayes, P. Budylowski, D. Richard, H. Maan, J. Aguiar, K. Baid, M. D’Agostino, J. Ang, B. Tremblay, S. Afkhami, M. Karimzadeh, A.

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COVID19 molecular epidemiology outreach publications SARS-CoV-2 virus epidemiology

OpEd: SARS-CoV-2 variants of concern remind us that we underestimate biology at our own peril

March 16, 2021March 16, 2021 agmcarthur

Imagine a tiny molecular machine armed with a program to infect human cells, subvert their defenses and make copies of itself to infect neighboring cells

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antibiotic resistance big data genomics publications

Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance

January 8, 2021January 8, 2021 agmcarthur

Kara K. Tsang, Finlay Maguire, Haley L. Zubyk, Sommer Chou, Arman Edalatmand, Gerard D. Wright, Robert G. Beiko, & Andrew G. McArthur Microbial Genomics, in

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lab members publications virulence

Bacterial type VII secretion: an important player in host‐microbe and microbe‐microbe interactions

January 8, 2021January 8, 2021 agmcarthur

Hiu‐Ki R. Tran, Dirk W. Grebenc, Timothy A. Klein, John C. Whitney Molecular Microbiology, in press. Type VII secretion systems (T7SSs) are poorly understood protein

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bioinformatics genomics molecular epidemiology publications virulence

Whole genome sequence of Corynebacterium kroppenstedtii isolated from a case of recurrent granulomatous mastitis

December 29, 2020February 7, 2021 agmcarthur

Charlie Tan, Fang-I Lu, Patryk Aftanas, Kara Tsang, Samira Mubareka, Adrienne Chan, & Robert Kozak IDCases. 2020. 23:e01034. We describe the case of a 33-year-old

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antibiotic resistance genomics publications

Recurrent multidrug-resistant Salmonella enterica serovar Typhimurium bacteremia in a returned traveller

December 16, 2020December 30, 2020 agmcarthur

Adam S Komorowski, Xena X Li, Eva Piessens, Andrew G McArthur, & Ameen Patel Journal of the Association of Medical Microbiology and Infectious Disease Canada,

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bioinformatics genomics publications virulence

Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

December 16, 2020December 30, 2020 agmcarthur

Shehryar Ahmad, Kara L Tsang, Kartik Sachar, Dennis Quentin, Tahmid M Tashin, Nathan P Bullen, Stefan Raunser, Andrew G McArthur, Gerd Prehna, & John C

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COVID19 publications

A regional Canadian expert consensus on recommendations for restoring exercise and pulmonary function testing in low and moderate-to-high community prevalence coronavirus disease 2019 (COVID-19) settings

November 20, 2020December 30, 2020 agmcarthur

Sarah Khan, Kara K Tsang, Dominik Mertz, Myrna Dolovich, Marcel Tunks, Catherine Demers, Kelly Hassall, Neil Maharaj, Karen Margallo, Maureen Cividino, Zain Chagla, & MyLinh

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